Endocrine Abstracts

Acromegaly in pregnancy is rare. There is limited literature on the use of medical therapy to treat this condition. We report for the first time somatostatin analogue use in a woman presenting with newly diagnosed Acromegaly in pregnancy to treat visual field loss.This is the case of a 32 year old woman with a background of anxiety, depression, asthma and smokes. The patient underwent brain imaging for recurrent headache at 11 weeks gestation. At this ti...

Apparent mineralocorticoid excess is a rare syndrome with few reported literature entries. Liquorice tea is a common dietary supplement often used as a slimming aid.We present the case of a 50 year old woman who presented with a two week history of headache, nausea and light sensitivity. Background medical history consisted of irritable bowel syndrome, tubal ligation, thrombosis of a retinal vessel at 17 years of age and a smoker of 10 pack year.<p c...

Acromegaly is a rare disease characterised by excessive Growth Hormone production. Subfertility is common in acromegaly and has various aetiologies, therefore pregnancy in acromegaly is rare. The limited data that is available would suggest that pregnancy in acromegaly is generally safe. However, there have been reports of tumour expansion during pregnancy. Here we present a case of first presentation of acromegaly in pregnancy and subsequent rescue of visual field loss with s...

We are presenting a case report of 82-year-old patient admitted at Cork University Hospital on 3 July 2015 for investigation of complete ptosis and ophthalmoplegia of left eye which had occurred in couple of weeks time. Initially patient was referred to ophthalmology department by his GP and ophthalmologist found left ophthalmopathy with complete ptosis and referred patient to medical for stroke work up. CT Brain showed abnormal mass in pituitary fossa. MRI Pituitary showed mu...

Bone turnover markers (BTMs) may have a role in assessing bone turnover and response to intervention in Paget’s disease. We examined the clinical utility of bone turnover markers at diagnosis through analysis of our database of patients with radiographically confirmed Paget’s disease.We identified 36 patients (20 men); mean age at diagnosis was 71.6 years (range 54–84). Radionuclide imaging identified that 64% had polyostotic disease, with...

Introduction: Pancreatic neuroendocrine tumours (pNETs) are the main cause of mortality in patients with multiple endocrine neoplasia type 1 (MEN1). The CLARINET study demonstrated that somatostatin analogue treatment improved progression free survival in patients with enteropancreatic NETs but little is known about the role of SSA in preventing progression of pNETs in MEN1 (1). Many centres have started using SSA treatment in MEN1 patients with enlarging pNETs or tumours &#62...

Introduction: Pheochromocytoma and Paraganglioma (PPGL) are neuroendocrine tumours arising from chromaffin cells in the adrenal medulla or ganglia in the autonomic nervous system. ~40% of PPGL arise due to germline mutation (commonly SDHx) and sporadic tumours frequently have causative somatic mutations. 15-20% of PPGL behave in a malignant manner. ~95% PPGL express somastostatin receptors and are GaDOTATATE avid. Lutathera® is a commercially available PR...